Related Experiment Video
Updated: Aug 2, 2026

17:14
In vivo and in vitro Studies of Adaptor-clathrin Interaction
Published on: January 26, 2011
Clathsterol, a novel anti-HIV-1 RT sulfated sterol from the sponge Clathria species
1School of Chemistry and School of Medicine, Tel-Aviv University, Ramat-Aviv 69978, Israel.
Journal of Natural Products
|November 27, 2001
Abstract:
As part of a search for novel inhibitors of humandeficiency virus type 1 (HIV-1) reverse transcriptase (RT), the MeOH-EtOAc extract of a Red Sea sponge, Clathria sp., was shown to be active. Bioassay-guided fractionation of the extract yielded a novel sterol sulfate, clathsterol (1), which is responsible for the activity and is active at a concentration of 10 microM. The structure of 1 was established mainly by interpretation of spectral data and a chemical transformation.

