Related Experiment Video
Updated: Aug 14, 2026

System for Efficacy and Cytotoxicity Screening of Inhibitors Targeting Intracellular Mycobacterium tuberculosis
Published on: April 5, 2017
Inhibition of Mycobacterium tuberculosis growth by saringosterol from Lessonia nigrescens
G A Wächter1, S G Franzblau, G Montenegro
1Department of Pharmacology and Toxicology, College of Pharmacy, The University of Arizona, 1703 E. Mabel Street, Tucson, Arizona 85721-0207, USA.
Abstract:
Assay-guided fractionation of an antitubercular extract obtained from Lessonia nigrescens yielded the phytosterol saringosterol as its active component. No appreciable toxicity against Vero cells was observed for this compound. Saringosterol was also synthesized by oxidation of fucosterol. The MIC values for antitubercular activity of saringosterol and its 24S and 24R epimers were determined as 0.25, 1, and 0.125 microg/mL.
More Related Videos
Related Concept Videos
Pulmonary Tuberculosis V
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...
Tuberculosis
Clinical Significance of Antibiotic Resistance
Antiprotozoal Agents

