Related Experiment Video

Updated: Aug 11, 2026

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
10:44

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs

Published on: May 15, 2019

Cilostazol

J W Cheng1

  • 1Arnold & Marie Schwartz College of Pharmacy and Health Sciences, Long Island University, New York, New York, USA.

Heart Disease (Hagerstown, Md.)
|November 27, 2001
PubMed

Insights

Cilostazol effectively treats intermittent claudication by inhibiting phosphodiesterase III. However, it is not recommended for patients with severe heart failure due to potential risks observed in similar medications.

Area of Science:

  • Pharmacology
  • Vascular Medicine

Background:

  • Intermittent claudication is a common symptom of peripheral artery disease.
  • Phosphodiesterase III inhibitors offer a therapeutic option for managing this condition.

Purpose of the Study:

  • To evaluate the efficacy and safety of cilostazol for symptomatic intermittent claudication.

Main Methods:

  • Review of existing clinical studies and pharmacological data on cilostazol.
  • Analysis of contraindications and potential adverse effects.

Main Results:

  • Cilostazol demonstrates effectiveness in improving symptoms of intermittent claudication.
  • The drug is generally well-tolerated.
  • Contraindicated in patients with severe heart failure due to class-related risks.

Conclusions:

  • Cilostazol is a viable treatment for intermittent claudication.
  • Further research is needed to ascertain long-term benefits and safety profiles.

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