Mechanisms of cell volume regulation and possible nature of the cell volume sensor

In animal organisms, cell volume undergoes dynamic changes in many physiological and pathological processes. To protect themselves against lysis and apoptosis and to maintain an optimal concentration of intracellular enzymes and metabolites, most animal cells actively regulate their volume. In the present review, we shortly summarize the data on ion transport mechanisms involved in regulatory volume decrease (RVD) and regulatory volume increase (RVI) with an emphasis on unresolved aspects of this problem such as: (i) how cells sense their volume changes; (ii) what signals are generated upon cell volume alterations; and (iii) how these signals are transferred to the ion transport systems executing cell volume regulation.