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Synthesis and antiproliferative activity of some thiazolylbenzimidazole-4,7-diones
L Garuti1, M Roberti, A Pession
1Department of Pharmaceutical Science, University of Bologna, via Belmeloro 6, I-40126, Bologna, Italy. lauga@alma.unibo.it
Bioorganic & Medicinal Chemistry Letters
|November 27, 2001
Abstract:
Some thiazolylbenzimidazole-4,7-diones were synthesized and tested in vitro on two tumor cell lines. Compounds 2d and 2e show a very good activity on K562 cells, whereas compounds 2a and 2b are active on SW620 cells. The importance of the methoxy group on the quinone moiety is confirmed and the function at 4-position of the thiazole ring plays a determining role for the activity.