[Comparison of clinical outcome between allogeneic peripheral blood stem cell transplantation and bone marrow...

To compare the clinical outcome of allogeneic peripheral blood stem cell transplantation(PBSCT) with that of bone marrow transplantation(BMT).

Twenty-six patients received allo-BMT and 24 received allo-PBSCT in our hospital between August 1991 and September 1998. Conditioning regimens were CY 120 mg/kg plus STBI 9-10 Gy or BU 16 mg/kg or Mel 140-160 mg/m2 plus CY 120 mg/kg.

Twenty-three patients of PBSCT and 24 of BMT group engrafted successfully. The median follow-up duration was 352(19-745) days for the PBSCT group and 546(19-2,329) days for the BMT group. Transplant-related death was 4(16.7%) patients in the PBSCT and 7(26.9%) in BMT group (P = 0.38). Three(12.5%) patients in PBSCT and 5(19.2%) in BMT group relapsed(P = 0.27). The 2-year probabilities of disease-free survival(DFS) for PBSCT and BMT group were (67.9 +/- 11.3)% and (57.7 +/- 9.7)%, respectively(P = 0.24). aGVHD occurred in 6(25%) patients in the PBSCT and 6 (23.1%) in the BMT group (P = 0.624), while cGVHD did in 13(56.5%) and 1 (3.85%), respectively (P = 0.0002).

The clinical outcome of allo-PBSCT is similar to allo-BMT, except for a higher incidence of cGVHD.