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[Expression of cyclin D1 mRNA in acute leukemia patients and its clinical implication]
Objective:
To determine the expression of cyclin D1 gene in patients with acute leukemia and evaluate the relationship between cyclin D1 expression and treatment outcomes.
Methods:
The expression of cyclin D1 mRNA was determined in bone marrow cells from 65 acute leukemia patients and 5 normal subjects by RT-PCR technique.
Results:
Cyclin D1 mRNA was negative in normal bone marrow cells. Among leukemia patients, the rate of cyclin D1 expression was 26.2%, and the highest(63.6%) rate was in the relapse group and the lowest(8.3%) in the CR group. Relapse rate of the patients with cyclin D1 expression was higher than that of those with negative expression over 1-13 months follow-up.
Conclusion:
Overexpression of cyclin D1 does exist in acute leukemia patients and is correlated with the disease progression, especially with relapse.