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Updated: Jul 9, 2026
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Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma
Published on: October 14, 2016
Comparative frequency of bone sarcomas among different racial groups
1Department of Orthopaedic Surgery, People's Hospital, Beijing Medical University, Beijing 100044, China.
Chinese Medical Journal
|November 28, 2001
Summary
This study compares bone tumor data from China, Japan, and the US. Osteosarcoma (OS) is more common in Asia, while chondrosarcoma (CS) is more frequent in the US, with differing age distributions and skeletal locations.
Area of Science:
- Oncology
- Epidemiology
- Orthopedics
Background:
- Bone tumors represent a diverse group of neoplasms with varying global incidence.
- Understanding geographic and demographic variations in bone tumor types is crucial for epidemiology and clinical practice.
Purpose of the Study:
- To conduct a comparative analysis of primary bone tumor data from China, Japan, and the United States.
- To investigate differences in bone tumor distribution by race, age, sex, and skeletal location.
Main Methods:
- Utilized data from the Chinese Bone Tumor Registry (1957-1988), Japanese Bone Tumor Registry (1972-1990), and Mayo Clinic, USA (11,087 cases).
- Included supplementary data from SEER (1973-1987) and Memorial Sloan-Kettering Cancer Center.
- Employed frequency analysis using tumor ratios to osteosarcoma for reliability.
Main Results:
- Osteosarcoma (OS) relative frequency was higher in China and Japan than in the US; Americans showed more OS in flat bones.
- Chondrosarcoma (CS) relative frequency was higher in the US group; CS patients were younger in China.
- Ewing sarcoma incidence was higher in Western populations; chordoma was more frequent in Americans; giant cell tumors were more common in Asians.
Conclusions:
- Comparative analysis reveals significant geographic variations in bone tumor epidemiology.
- Findings offer valuable insights for the epidemiologic study and clinical diagnosis of bone tumors worldwide.
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