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[Local cutaneous side effects of interferons].

A Charron1, D Bessis, O Dereure

  • 1Service de Dermatologie-Phlébologie, Centre Hospitalier et Universitaire de Montpellier, Hôpital Saint-Eloi, 80, avenue Augustin-Fliche, F34295 Montpellier.

Presse Medicale (Paris, France : 1983)
|November 28, 2001
PubMed
Summary

Skin reactions to interferon (IFN) treatment, though uncommon, can be serious. This review covers their mechanisms, management, and prevention, emphasizing patient education for self-injection safety.

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Area of Science:

  • Dermatology
  • Hepatology
  • Pharmacology

Context:

  • Interferon (IFN) therapy is increasingly used for chronic hepatitis C.
  • Skin reactions are an underappreciated adverse effect of IFN treatment, ranging from 5-12% of all side effects.
  • Reactions can be local, at the injection site, or systemic.

Purpose:

  • To review the literature on local skin reactions associated with different interferons.
  • To investigate the pathophysiological mechanisms of these reactions.
  • To outline current management strategies and preventive measures.

Summary:

  • Local skin reactions to interferon injections are categorized into minor (e.g., erythema, eczema) and severe (e.g., necrosis, vasculitis).
  • Minor reactions have minimal clinical impact, while severe reactions necessitate treatment cessation.

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  • Effective prevention strategies include patient education on aseptic self-injection techniques, site rotation, and vigilant self-monitoring.

    • Impact:

    • Highlights the importance of recognizing and managing skin reactions during interferon therapy.
    • Provides a framework for clinicians to address adverse dermatological events.
    • Emphasizes patient education and self-care to mitigate treatment complications and ensure therapeutic continuity.