Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Tissue-engineered skin. Current status in wound healing.

Y M Bello1, A F Falabella, W H Eaglstein

  • 1Department of Dermatology and Cutaneous Surgery, University of Miami School of Medicine, Miami, Florida, USA.

American Journal of Clinical Dermatology
|November 28, 2001
PubMed
Summary

Tissue-engineered skin offers advanced wound healing solutions, overcoming autograft limitations like donor site morbidity. Various engineered skin products are available or in development, providing new treatment options.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The healing effect of over-the-counter wound healing agents applied under semiocclusive film dressing.

The British journal of dermatology·2014
Same author

Challenges encountered in dermatologic drug development.

Actas dermo-sifiliograficas·2010
Same author

Tissue-engineered skin in the healing of wound stumps from limb amputations secondary to purpura fulminans.

Pediatric dermatology·2003
Same author

The role of graftskin (Apligraf) in difficult-to-heal venous leg ulcers.

Journal of wound care·2002
Same author

Treatment of refractory, atypical lower extremity ulcers with tissue-engineered skin (Apligraf).

Archives of dermatology·2001
Same author

Recombinant human platelet-derived growth factor gel speeds healing of acute full-thickness punch biopsy wounds.

Journal of the American Academy of Dermatology·2001

Area of Science:

  • Regenerative Medicine
  • Biomaterials Science
  • Wound Healing

Background:

  • Autografts for wound healing present challenges including donor site pain, scarring, and infection.
  • Tissue-engineered skin substitutes have been developed to address these limitations.
  • Numerous commercial and investigational skin substitutes exist, offering diverse approaches.

Purpose of the Study:

  • To review the landscape of tissue-engineered skin substitutes.
  • To highlight the advantages and limitations of various available and developing products.
  • To discuss the potential of these novel wound healing options.

Main Methods:

  • Review of commercially available and investigational tissue-engineered skin products.
  • Categorization based on composition (e.g., cellular vs. acellular, allogeneic vs. xenogeneic).

Related Experiment Videos

  • Discussion of key characteristics, applications, and cultivation requirements.

    • Main Results:

    • Cultured epidermal autografts require 3 weeks for cultivation but offer permanent coverage.
    • Acellular matrices like Alloderm and Integra prepare the wound bed and promote healing.
    • Living skin equivalents (e.g., Apligraf, Dermagraft, TransCyte, OrCel) offer immediate use but vary in composition and clinical data.
    • Dermal substitutes derived from pigs (Oasis, E-Z-Derm) are also noted.

    Conclusions:

    • Tissue-engineered skin substitutes provide promising alternatives to traditional wound treatments.
    • Further clinical trials are necessary to fully evaluate the risks and benefits of these novel products.
    • These engineered skin options represent a significant advancement in wound care management.