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Related Experiment Videos

Prolactin in human systemic lupus erythematosus.

L J Jara1, O Vera-Lastra, J M Miranda

  • 1Rheumatology Department, Hospital de Especialidades, Centro Medico Nacional La Raza, Mexico City, Mexico. smre@infosel.net.mx

Lupus
|November 28, 2001
PubMed
Summary

Elevated prolactin (PRL) is linked to systemic lupus erythematosus (SLE) activity. This neuroendocrine-immune interaction may drive SLE pathogenesis and severity, offering new therapeutic targets.

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Area of Science:

  • Immunology
  • Endocrinology
  • Rheumatology

Background:

  • Accumulating evidence suggests a role for elevated serum prolactin (PRL) in the pathogenesis and clinical expression of systemic lupus erythematosus (SLE).
  • Hyperprolactinemia (HPRL) is observed in 20-30% of SLE patients, potentially influencing disease activity, particularly during pregnancy.

Purpose of the Study:

  • To explore the association between prolactin (PRL) and the clinical activity and pathogenesis of systemic lupus erythematosus (SLE).
  • To investigate the potential role of PRL as a promoter of SLE activity and severity, including its involvement in organ-specific manifestations like lupus nephritis and CNS SLE.

Main Methods:

  • Review of clinical and experimental studies investigating the relationship between PRL levels and SLE activity.
  • Analysis of PRL and cytokine levels in urine and cerebrospinal fluid (CSF) of SLE patients.

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  • Examination of PRL production by lymphocytes in active SLE patients.

    • Main Results:

    • HPRL is associated with SLE clinical activity, especially during pregnancy, and may contribute to SLE onset in some patients.
    • Elevated PRL and IL-6 are found in urine of lupus nephritis patients and CSF of CNS SLE patients, suggesting PRL's role in organ-specific pathology.
    • Lymphocytes in active SLE produce increased PRL, indicating extrapituitary PRL involvement in aberrant immune processes.

    Conclusions:

    • Prolactin (PRL) acts as a bridge between the neuroendocrine and immune systems in SLE, participating in immune and inflammatory processes.
    • Understanding the interactions between PRL, cytokines, autoantibodies, and organ involvement is crucial for managing SLE.
    • Further research into these neuroendocrine-immune interactions may lead to novel therapeutic strategies for SLE.