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Genome structure of Ebola virus subtype Reston: differences among Ebola subtypes. Brief report
T Ikegami1, A B Calaor, M E Miranda
1Department of Virology 1, National Institute of Infectious Diseases, Tokyo, Japan.
Archives of Virology
|November 28, 2001
Abstract:
We determined the complete genome sequence of Ebola virus subtype Reston (EBO-R) in the Philippines in 1996. The deduced transcriptional signals were highly conserved among Ebola viruses except for the stop signal of L genes. The intergenic regions were composed of 4 to 7 nucleotides, and of 2 characteristic overlaps and a long intergenic region. The glycoprotein (GP) had several amino acid differences from EBO-R isolated in 1989 and 1992. The variety of GP sequences strongly suggests the independent introduction of EBO-R from unknown natural reservoirs in 1996.