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Agranulocytosis and granulocytopenia associated with quetiapine
H G Ruhé1, H E Becker, P Jessurun
1MFO Psychiatrie AMC/de Meren, Academic Medical Centre, P.O. Box 22660, 1100 DD, Amsterdam, The Netherlands.
Acta Psychiatrica Scandinavica
|November 28, 2001
Abstract
Objective:
Quetiapine is a recently introduced atypical antipsychotic. Although adverse effects are mainly mild, more serious infrequent adverse effects including leucopenia are mentioned.
Method:
We describe three case-reports concerning haematological adverse effects of quetiapine.
Results:
Quetiapine was associated with leucopenia in two patients and clinically apparent agranulocytosis in one patient.
Conclusion:
Although a definite association has not been proven, clinicians should be aware of the possibility of agranulocytosis while using quetiapine. Further post-marketing surveys are required.