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Related Experiment Videos

Oestrogen withdrawal associated psychoses.

V Mahé1, A Dumaine

  • 1Department of Psychiatry, City Hospital of Meaux, 6-8 rue Saint-Fiacre, 77100 Meaux, France.

Acta Psychiatrica Scandinavica
|November 28, 2001
PubMed
Summary

Oestrogen withdrawal may trigger psychotic disorders outside of the postpartum period. This finding supports the role of oestrogen withdrawal in puerperal and related psychoses.

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Area of Science:

  • Neuroendocrinology
  • Psychiatry
  • Reproductive Medicine

Background:

  • Oestrogen withdrawal is a proposed cause of puerperal psychoses.
  • Oestrogen withdrawal also occurs in non-puerperal states.

Purpose of the Study:

  • To investigate the association between oestrogen withdrawal and psychotic disorders outside of the puerperium.
  • To evaluate the relevance of the oestrogen withdrawal hypothesis in a broader context.

Main Methods:

  • Systematic literature review of case reports from 1960-2000.
  • Identification of cases linking psychotic disorders with non-puerperal oestrogen withdrawal.

Main Results:

  • 26 cases reported an association between psychotic disorders and oestrogen withdrawal.
  • Psychotic episodes were typically short and reversible.
  • Recurrences were observed upon repeated oestrogen withdrawal.
  • Puerperal psychosis history was common among patients.

Conclusions:

  • The oestrogen withdrawal hypothesis is relevant to psychotic episodes beyond the puerperium.
  • This extends the clinical significance of oestrogen withdrawal in puerperal and related psychoses.

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