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Internal jugular vein thrombosis after assisted conception therapy
R Arya1, H A Shehata, R K Patel
1Department of Haematology, King's College Hospital, London, UK. roopen.arya@kcl.ac.uk
British Journal of Haematology
|November 28, 2001
Summary
Ovarian stimulation for in vitro fertilization (IVF) can increase blood clot risk. Five women developed upper extremity venous thrombosis during early pregnancy after IVF, highlighting the need for patient counseling and risk assessment.
Area of Science:
- Reproductive Medicine
- Hematology
- Obstetrics
Background:
- Superovulation therapy for assisted conception may induce a hypercoagulable state.
- Venous thromboembolism is a serious complication during pregnancy.
- Ovarian stimulation protocols are widely used in assisted reproductive technologies.
Purpose of the Study:
- To report cases of upper extremity venous thrombosis in women undergoing ovarian stimulation for IVF.
- To highlight potential risks associated with assisted conception.
- To inform clinical practice regarding patient counseling and thromboprophylaxis.
Main Methods:
- Retrospective case series identification.
- Review of patient records for women conceiving via IVF.
- Analysis of clinical presentation, treatment, and outcomes.
Main Results:
- Five cases of upper extremity venous thrombosis were identified in women 7-10 weeks pregnant post-IVF.
- Patients presented with neck pain and swelling.
- Three patients had ovarian hyperstimulation syndrome; two had inherited thrombophilia. Four received thromboprophylaxis prior to presentation.
Conclusions:
- Thrombosis is an uncommon but significant complication of IVF.
- Pre-treatment counseling for IVF patients regarding hypercoagulable risks is essential.
- Thrombophilia screening and optimized thromboprophylaxis strategies may benefit high-risk individuals.