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Related Experiment Videos

Mohs micrographic surgery-induced pemphigus.

M G Duick1, B Zaks, R L Moy

  • 1Department of Internal Medicine, North-western University School of Medicine, Chicago, Illinois, USA.

Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [Et Al.]
|November 28, 2001
PubMed
Summary
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Mohs surgery may trigger pemphigus, an autoimmune blistering disease, in surgical wounds. This condition requires differentiation from typical wound healing complications.

Area of Science:

  • Dermatology
  • Autoimmune Diseases
  • Surgical Oncology

Background:

  • Pemphigus is an autoimmune blistering disease characterized by intraepidermal blisters and autoantibodies against keratinocytes.
  • Surgical trauma is an infrequently reported trigger for pemphigus onset.
  • Mohs micrographic surgery is a specialized technique for skin cancer removal.

Observation:

  • A case report details pemphigus developing in a surgical wound after Mohs surgery for squamous cell carcinoma.
  • Preoperative biopsy of the lesion did not indicate pemphigus.
  • Postoperative biopsy confirmed pemphigus development within the Mohs surgical site.

Findings:

  • Pemphigus manifested in the Mohs surgical wound post-excision of squamous cell carcinoma.
  • The patient's preoperative lesion biopsy was negative for pemphigus.

Related Experiment Videos

  • Histopathology of the postoperative wound confirmed the diagnosis of pemphigus.

    • Implications:

    • Mohs surgery, similar to other surgical procedures, may act as a nonspecific trigger for pemphigus.
    • Postoperative pemphigus requires careful differentiation from wound infections and other healing issues.
    • This case highlights the potential for iatrogenic induction of autoimmune blistering diseases.