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CD8+CD28- T suppressor cells and the induction of antigen-specific, antigen-presenting cell-mediated suppression of

R Cortesini1, J LeMaoult, R Ciubotariu

  • 1Department of Pathology, Columbia University, New York, New York 10032, USA.

Immunological Reviews
|November 28, 2001
PubMed

Human CD8+CD28- suppressor T cells (Ts) are a subset of T cells generated in the course of in vitro and in vivo immunizations. Ts recognize MHC class I:peptide complexes and inhibit the reactivity of T helper cells (Th) with cognate antigen specificity. We have demonstrated for the first time that CD8+CD28- Ts represent a unique subset of regulatory cells that induces the differentiation of tolerogenic antigen-presenting cells, initiating a suppressive loop which results in the induction and spreading of Th unresponsiveness.

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