Salsolinol is a putative endogenous neuro-intermediate lobe prolactin-releasing factor

¹Neuroendocrine Research Laboratory, Department of Human Morphology and Developmental Biology, Semmelweis University, Budapest, Hungary.

|November 28, 2001

Summary

Researchers identified (R)-salsolinol (SAL) as a prolactin-releasing factor (PRF) in the pituitary gland. This dopamine-related compound selectively stimulates prolactin secretion in vivo and may be synthesized in situ for pituitary regulation.

Area of Science:

Neuroendocrinology
Reproductive Biology
Molecular Endocrinology

Background:

The prolactin-releasing factor (PRF) from the pituitary neuro-intermediate lobe has been a long-standing research target.
Dopamine-related compounds are implicated in pituitary hormone regulation.

Purpose of the Study:

To isolate and identify a prolactin-releasing factor (PRF) from the pituitary neuro-intermediate lobe.
To investigate the role of (R)-salsolinol (SAL) in prolactin secretion.

Main Methods:

High-pressure liquid chromatography with electrochemical detection (HPLC-ECD) and gas chromatography/mass spectrometry (GC/MS) for compound identification.
Measurement of SAL concentrations in rat pituitary extracts and plasma prolactin levels.
In vivo and in vitro studies using pituitary cell cultures and hypophysectomized rats with anterior lobe transplants.
Dopamine D2 receptor binding assays.

Main Results:

(R)-salsolinol (SAL), a dopamine-related tetrahydroisoquinoline, was identified in rat pituitary and median eminence extracts.
SAL concentrations in the neuro-intermediate lobe increased in parallel with plasma prolactin during suckling stimulus in lactating rats.
SAL selectively stimulated prolactin secretion in vivo and in vitro, without affecting other pituitary hormones.
SAL does not interact with the dopamine D2 receptor but binds specifically to pituitary homogenates.

Conclusions:

(R)-salsolinol (SAL) is synthesized in situ within the pituitary gland.
SAL acts as a potent and selective stimulator of prolactin secretion.
SAL plays a significant role in the physiological regulation of pituitary prolactin secretion.

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Salsolinol is a putative endogenous neuro-intermediate lobe prolactin-releasing factor

Area of Science:

Background:

Purpose of the Study:

Main Methods:

Main Results:

Conclusions:

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