Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hypothalamic involvement in chronic migraine.

M F Peres1, M Sanchez del Rio, M L Seabra

  • 1Sao Paulo Headache Center, R Maestro Cardim, 887 01323-001, Sao Paulo SP, Brazil. marioperes@yahoo.com

Journal of Neurology, Neurosurgery, and Psychiatry
|November 28, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Resistant and refractory migraine - two different entities with different comorbidities? Results from the REFINE study.

The journal of headache and pain·2024
Same author

Results from a synthetic model of the ITER XRCS-Core diagnostic based on high-fidelity x-ray ray tracing.

The Review of scientific instruments·2024
Same author

Beamline simulations using monochromators with high d-spacing crystals.

Journal of synchrotron radiation·2022
Same author

Calcitonin gene-related peptide in migraine: from pathophysiology to treatment.

Neurologia·2022
Same author

1st Post-European Headache Federation Meeting: a review of the latest developments presented at the 2020 European Headache Federation Congress.

Revista de neurologia·2021
Same author

High social jetlag is correlated with nocturnal inhibition of melatonin production among night workers.

Chronobiology international·2021

Chronic migraine (CM) involves hypothalamic dysfunction, indicated by altered nocturnal hormone secretion. Specifically, patients showed abnormal prolactin, cortisol, and melatonin patterns, suggesting chronobiologic dysregulation.

Area of Science:

  • Neuroendocrinology
  • Chronobiology
  • Headache Medicine

Background:

  • Chronic migraine (CM) affects 2-3% of the population and is often comorbid with other disorders.
  • Hypothalamic dysfunction is suspected in CM pathogenesis but has not been directly studied.
  • Nocturnal hormonal secretion patterns in CM patients remain largely uninvestigated.

Purpose of the Study:

  • To investigate hypothalamic involvement in chronic migraine.
  • To measure nocturnal secretion of melatonin, prolactin, growth hormone, and cortisol in CM patients.
  • To correlate hormonal changes with comorbid conditions like insomnia.

Main Methods:

  • Collected 338 blood samples (13 per patient) from 17 CM patients and 9 healthy controls.
  • Measured hormone concentrations (melatonin, prolactin, growth hormone, cortisol) hourly for 12 hours.

Related Experiment Videos

  • Assessed for comorbid disorders in all participants.

    • Main Results:

    • CM patients exhibited abnormal hypothalamic hormone secretion patterns.
    • Observed were decreased nocturnal prolactin peaks and increased cortisol levels.
    • A delayed nocturnal melatonin peak was noted in CM patients, with lower levels in those with insomnia.

    Conclusions:

    • Findings support hypothalamic dysfunction in CM, characterized by chronobiologic dysregulation.
    • A potential hyperdopaminergic state may be present in CM patients.
    • Insomnia appears to be a significant factor influencing the observed hormonal changes.