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Onset of multiple sclerosis associated with anti-TNF therapy
1Division of Brain Mapping, UCLA School of Medicine, Los Angeles, CA, USA. nsicotte@ucla.edu
Neurology
|November 28, 2001
Abstract:
Therapies aimed at inhibiting tumor necrosis factor (TNF), a proinflammatory cytokine implicated in autoimmune disease are effective, especially for rheumatoid arthritis. We report a patient with new onset MS closely associated with the initiation of anti-TNF therapy for juvenile rheumatoid arthritis. It is possible that the inhibition of TNF triggered MS in this individual.