Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Polymorphisms in hypocretin/orexin pathway genes and narcolepsy.

B R Olafsdóttir1, D B Rye, T E Scammell

  • 1deCODE genetics Inc, Reykjavík, Iceland.

Neurology
|November 28, 2001
PubMed
Summary

This study investigated the genetic links between narcolepsy and hypocretin (also known as orexin) signaling. Researchers found no significant association between narcolepsy and genetic variations in hypocretin or its receptors.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Corticotropin-Releasing Hormone (CRH) in Murine Narcolepsy: What Do Genetic and Immune Models Tell Us?

Journal of sleep research·2025
Same author

Brain age prediction using deep learning uncovers associated sequence variants.

Nature communications·2019
Same author

Rare and Common Variants Conferring Risk of Tooth Agenesis.

Journal of dental research·2018
Same author

Genome-wide association study across European and African American ancestries identifies a SNP in DNMT3B contributing to nicotine dependence.

Molecular psychiatry·2017
Same author

15q11.2 CNV affects cognitive, structural and functional correlates of dyslexia and dyscalculia.

Translational psychiatry·2017
Same author

A rare missense mutation in CHRNA4 associates with smoking behavior and its consequences.

Molecular psychiatry·2016

Area of Science:

  • Neuroscience
  • Genetics
  • Sleep Medicine

Background:

  • The neuroexcitatory peptide hypocretin (orexin) and its receptors are implicated in narcolepsy.
  • Understanding the genetic basis of narcolepsy is crucial for developing targeted therapies.

Purpose of the Study:

  • To investigate the association between single-nucleotide polymorphisms (SNPs) in hypocretin and its receptors and narcolepsy in American and Icelandic patient cohorts.
  • To explore the role of genetic variations in hypocretin signaling in narcolepsy pathophysiology.

Main Methods:

  • Genotyping of American and Icelandic patients diagnosed with narcolepsy.
  • Analysis of single-nucleotide polymorphisms (SNPs) in the genes encoding hypocretin, hypocretin receptor-1, and hypocretin receptor-2.

Related Experiment Videos

Main Results:

  • No significant association was found between narcolepsy and the studied single-nucleotide polymorphisms in the genes for hypocretin or its receptors (hypocretin receptor-1 and hypocretin receptor-2).
  • Genetic variations in hypocretin signaling pathways do not appear to be a major risk factor for narcolepsy in these populations.

Conclusions:

  • The findings suggest that common genetic variations in hypocretin and its receptors are unlikely to be the primary cause of narcolepsy in the studied populations.
  • Further research may be needed to explore other genetic or environmental factors contributing to narcolepsy.