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Updated: Aug 16, 2026

Interview: Protein Folding and Studies of Neurodegenerative Diseases
Published on: July 16, 2008
New proteins from old diseases provide novel insights in cell biology
1Sidney Weisner Laboratory of Genetic Neurological Disease, Department of Neuroscience, Rose F. Kennedy Center for Research in Mental Retardation and Human Development, Albert Einstein College of Medicine, Bronx, NY 10461, USA. walkley@aecom.yu.edu
Abstract:
The lysosomal disease concept was developed by Hers in 1963. At the time, few could have imagined the breadth and depth of knowledge about cell biology that these disorders would reveal. With a collective hindsight of nearly four decades, it is fair to say that we have learned more about the lysosomal system of cells through the study of these rare diseases than by any other means. Given the advancements of the past year, it is apparent that some of the most significant insights are yet to come, as we delineate the last remaining and most enigmatic of these diseases.
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