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Related Experiment Videos

[Elastin and elastases. Past, present, and future].

L Robert1

  • 1Laboratoire de Recherche en Ophtalmologie, Hôtel Dieu, 1 Place du Parvis Notre Dame, 75181 Paris.

Journal De La Societe De Biologie
|November 29, 2001
PubMed
Summary
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Extracellular matrix (ECM) components evolved over time, with elastin emerging specifically in vertebrates. This protein

Area of Science:

  • Biochemistry and evolutionary biology
  • Focus on the composition and evolution of the extracellular matrix (ECM).

Context:

  • The extracellular matrix (ECM) is crucial for tissue structure and function.
  • ECM comprises collagens, elastin, proteoglycans, glycosaminoglycans, and glycoproteins.
  • Three ECM classes originated during the Cambrian explosion in early invertebrates.

Purpose:

  • To investigate the evolutionary origin and functional decline of elastin.
  • To understand the post-synthetic modifications affecting elastin's rheological properties.
  • To integrate knowledge of elastin's emergence and decay into organismal development and aging.

Summary:

  • Elastin is a unique ECM component that appeared exclusively in vertebrates.
  • Post-synthetic modifications lead to the progressive loss of elastin's essential rheological functions.

Related Experiment Videos

  • Mechanisms of elastin's origin and decay are understood for developmental and aging processes.

    • Impact:

    • Provides insights into the evolutionary trajectory of ECM components.
    • Highlights the molecular basis for age-dependent functional decline in vertebrates.
    • Informs potential therapeutic strategies targeting age-related tissue degeneration.