Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[The elastin-laminin receptor].

T Fülöp1, M P Jacob, J Wallach

  • 1Laboratoire de Bio-gérontologie, Institut Universitaire de Gériatrie et Département de Médecine, Université de Sherbrooke, Sherbrooke, Québec, Canada.

Journal De La Societe De Biologie
|November 29, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Carrier-envelope offset stable, coherently combined ytterbium-doped fiber CPA delivering 1  kW of average power.

Optics letters·2020
Same author

Formation of CN Radical from Nitrogen and Carbon Condensation and from Photodissociation in Femtosecond Laser-Induced Plasmas: Time-Resolved FT-UV-Vis Spectroscopic Study of the Violet Emission of CN Radical.

The journal of physical chemistry. A·2020
Same author

Adipokines as atherothrombotic risk factors in obese subjects: Associations with haemostatic markers and common carotid wall thickness.

Nutrition, metabolism, and cardiovascular diseases : NMCD·2017
Same author

The c.-133A > G polymorphism in NPC1L1 gene influences the efficacy of ezetimibe monotherapy on apolipoprotein A1 in hyperlipidemic patients.

Die Pharmazie·2014
Same author

A comparative study on dyslipidaemia inducing diets in various rat strains.

Acta physiologica Hungarica·2014
Same author

Relationship between serum paraoxonase and homocysteine thiolactonase activity, adipokines, and asymmetric dimethyl arginine concentrations in renal transplant patients.

Transplantation proceedings·2013
Same journal

[Food safety of GMOs].

Journal de la Societe de biologie·2010
Same journal

[Placing on the market, breeders rights and growing genetically modified (GM) varieties].

Journal de la Societe de biologie·2010
Same journal

[Cultivation and environmental impacts of GMO crops].

Journal de la Societe de biologie·2010
Same journal

[Applications of genetically modified animals].

Journal de la Societe de biologie·2010
Same journal

[Why GMOs].

Journal de la Societe de biologie·2010
Same journal

[Mutations in renin-angiotensin system genes and kidney developmental anomalies].

Journal de la Societe de biologie·2010
See all related articles

Degraded elastin peptides trigger cellular responses via the elastin-laminin receptor (ELR). Understanding ELR signaling pathways, involving calcium and MAPK, aids in modulating cellular functions, especially in atherosclerosis.

Area of Science:

  • Biochemistry
  • Cell Biology
  • Extracellular Matrix Research

Context:

  • Elastin, a key extracellular matrix protein, degrades into peptides found in human sera.
  • These elastin peptides interact with specific cell types, including fibroblasts, immune cells, and endothelial cells.
  • The elastin-laminin receptor (ELR) mediates these cellular interactions.

Purpose:

  • To elucidate the signal transduction pathways activated by elastin peptides through the ELR.
  • To identify the molecular mechanisms underlying the biological effects of elastin peptides.
  • To provide a foundation for modulating these pathways in pathological contexts.

Summary:

  • Elastin peptides bind to the elastin-laminin receptor (ELR) on various cell types.
  • ELR activation involves a pertussis toxin-sensitive G-protein, leading to phospholipase C (PLC) activation.

Related Experiment Videos

  • PLC generates inositol trisphosphate (IP3) and diacylglycerol (DAG), increasing intracellular calcium and activating protein kinase C (PKC), which phosphorylates MAPK pathways (e.g., p42/p44 MAPK).

    • Impact:

    • Elucidating ELR signaling complexity offers therapeutic targets for diseases.
    • This research is crucial for understanding and potentially treating conditions like atherosclerosis.
    • Insights into ELR pathways can guide the development of novel therapeutic strategies.