Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[The elastases].

J G Bieth1

  • 1Laboratoire d'Enzymologie, INSERM U 392, Faculté de Pharmacie, 74 route du Rhin, 67400 Illkirch.

Journal De La Societe De Biologie
|November 29, 2001
PubMed
Summary
This summary is machine-generated.

Elastases are enzymes that break down fibrous elastin. Their activity varies, and they are implicated in diseases like emphysema and atherosclerosis.

Related Experiment Videos

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Insight into catalytic mechanism of papain-like cysteine proteinases: the case of D158.

Applied biochemistry and biotechnology·2004
Same author

The reaction of serpins with proteinases involves important enthalpy changes.

Biochemistry·2001
Same author

Insight into the catalysis of hydrolysis of four newly synthesized substrates by papain: a proton inventory study.

Biochemistry·2001
Same author

Evidence that translocation of the proteinase precedes its acylation in the serpin inhibition pathway.

The Journal of biological chemistry·2001
Same author

Effect of DNase on the activity of neutrophil elastase, cathepsin G and proteinase 3 in the presence of DNA.

FEBS letters·2000
Same author

DNA strongly impairs the inhibition of cathepsin G by alpha(1)-antichymotrypsin and alpha(1)-proteinase inhibitor.

The Journal of biological chemistry·2000

Area of Science:

  • Biochemistry
  • Enzymology

Context:

  • Elastases are proteinases that degrade fibrous elastin.
  • They are classified as serine, cysteine, or metalloproteinases.
  • Found in mammalian pancreas, phagocytes, and various bacteria.

Purpose:

  • To review the characteristics and roles of elastases.
  • To discuss methods for measuring elastolytic activity.
  • To highlight the involvement of elastases in pathological conditions.

Summary:

  • Elastolytic activity is diverse and not always correlated with catalytic efficiency.
  • Activity can be measured using native/labeled elastins or synthetic substrates.
  • Numerous natural and synthetic elastase inhibitors exist.

Impact:

  • Elastases contribute to diseases such as pulmonary emphysema, cystic fibrosis, infections, inflammation, and atherosclerosis.
  • Understanding elastase function is crucial for developing therapeutic strategies.