Docetaxel enhances the cytotoxicity of tetrahydropyranyladriamycin in a sequence-dependent manner
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Updated: Oct 3, 2026

Generation of Prostate Cancer Cell Models of Resistance to the Anti-mitotic Agent Docetaxel
Published on: September 8, 2017
T Egawa1, T Kubota, T Furukawa
1Department of Surgery, School of Medicine, Keio University, Tokyo, Japan.
Background:
Taxanes and anthracyclines are active against breast cancer. In this study we investigated the combined antitumor activity of these drugs, with particular regard to sequence-dependency.
Materials And Methods:
The combined antitumor activity of docetaxel and tetrahydropyranyladriamycin (THP) against two human breast cancer xenografts was assessed using an in vitro histoculture drug-response assay. The sequence-dependency of the combined cytotoxicity was evaluated by isobologram.
Results:
A synergistic antitumor activity of combined docetaxel + THP was exhibited against the R-27 xenograft when docetaxel was given first or simultaneously with THP. However, this synergism was diminished when THP was used before docetaxel. While an additive effect of combined docetaxel + THP was observed against MX-1 xenograft when docetaxel was given first or simultaneously with THP, this effect was not marked using the THP/docetaxel sequence.
Conclusion:
Docetaxel increased the antitumor activity of THP, but only when administered before or simultaneously with THP.
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