Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Low-density lipoprotein apheresis and changes in plasma components.

S Kojima1

  • 1Department of Clinical Research, Tohsei National Hospital, Sunto-gun, Shizuoka, Japan. skojima@jun.ncvc.go.jp

Therapeutic Apheresis : Official Journal of the International Society for Apheresis and the Japanese Society for Apheresis
|November 29, 2001
PubMed
Summary

Dextran-sulfate cellulose (DSC) apheresis effectively removes low-density lipoprotein (LDL) and other plasma proteins, potentially aiding in atherosclerosis and amyloidosis treatment. Bradykinin generation during DSC apheresis may improve circulation and cause hypotension in patients on ACE inhibitors.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Isolation and partial characterization of SSI-like protease inhibitors from Streptomyces.

FEMS microbiology letters·1992
Same author

Investigation into the 5-hydroxytryptamine-induced relaxation of the circular smooth muscle of guinea-pig stomach fundus.

European journal of pharmacology·1992
Same author

Binding of [3H]haloperidol to dopamine D2 receptors in the rat striatum.

The Journal of pharmacy and pharmacology·1992
Same author

Effects of recombinant tumour necrosis factor on antibody-dependent eosinophil-mediated damage to Schistosoma japonicum larvae.

Parasite immunology·1992
Same author

Anticoagulant action of rare earth metals.

Biochemistry international·1992
Same author

Prolonged circulation time in vivo of large unilamellar liposomes composed of distearoyl phosphatidylcholine and cholesterol containing amphipathic poly(ethylene glycol).

Biochimica et biophysica acta·1992

Area of Science:

  • Cardiovascular Medicine
  • Biochemistry
  • Hematology

Background:

  • Severe hypercholesterolemia requires effective management strategies.
  • Low-density lipoprotein (LDL) apheresis is a key treatment option.
  • Dextran-sulfate cellulose (DSC) column adsorption is a widely used apheresis technique.

Purpose of the Study:

  • To detail the plasma constituents adsorbed by DSC columns.
  • To explore the therapeutic implications of DSC apheresis.
  • To investigate the role of bradykinin in DSC apheresis.

Main Methods:

  • Analysis of plasma components adsorbed by DSC columns.
  • Review of clinical outcomes associated with DSC apheresis.
  • Examination of bradykinin generation pathways during apheresis.

Related Experiment Videos

Main Results:

  • DSC columns adsorb LDL, Lp(a), coagulation factors (XII, VII, VIII), vitamin E, and other proteins like vWF and HGF.
  • Adsorption of these factors may prevent or regress atherosclerosis.
  • DSC apheresis may benefit amyloidosis treatment.
  • Bradykinin generation via contact activation may improve circulation and cause hypotension, especially with ACE inhibitors.

Conclusions:

  • DSC apheresis offers broad plasma component removal beyond LDL.
  • Potential therapeutic benefits include atherosclerosis regression and amyloidosis treatment.
  • Bradykinin generation is a significant factor influencing DSC apheresis outcomes and side effects.