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Related Experiment Videos

Database-driven multi locus sequence typing (MLST) of bacterial pathogens.

M S Chan1, M C Maiden, B G Spratt

  • 1The Wellcome Trust Centre for the Epidemiology of Infectious Disease, University of Oxford, South Parks Road, Oxford OX1 3FY, UK. mchan@molbiol.ox.ac.uk

Bioinformatics (Oxford, England)
|November 29, 2001
PubMed
Summary
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Multi Locus Sequence Typing (MLST) provides unambiguous bacterial identification using gene sequencing. A new software system, mlstdb, enables global researchers to query sequence data against central databases online.

Area of Science:

  • Microbiology
  • Bioinformatics
  • Genetics

Background:

  • Multi Locus Sequence Typing (MLST) is an advanced bacterial typing method.
  • It analyzes DNA sequences of seven house-keeping genes for bacterial characterization.
  • MLST is crucial for tracking disease-causing and antibiotic-resistant bacterial strains.

Purpose of the Study:

  • To develop a robust software system for MLST data management and querying.
  • To facilitate global access to bacterial sequence databases.
  • To enhance the utility of MLST in public health and research.

Main Methods:

  • Development of a database-driven software system named mlstdb.
  • Utilizing Perl scripts for database table definition and interface generation.

Related Experiment Videos

  • Implementation of dynamic web pages for efficient database querying.

    • Main Results:

    • The mlstdb system is operational and used by laboratories worldwide.
    • It allows researchers to query nucleotide sequence data against central databases via the internet.
    • The system provides a user-friendly interface for accessing and analyzing MLST data.

    Conclusions:

    • The mlstdb software significantly enhances the accessibility and usability of MLST data.
    • It supports global efforts in bacterial surveillance and research.
    • This system standardizes and centralizes bacterial typing information.