Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Multiple system atrophy: cellular and molecular pathology.

D J Burn1, E Jaros

  • 1Regional Neurosciences Centre, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK. d.j.burn@ncl.ac.uk

Molecular Pathology : MP
|November 29, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Trajectories of pain over 6 years in early Parkinson's disease: ICICLE-PD.

Journal of neurology·2021
Same author

Progression of Neuropsychiatric Symptoms over Time in an Incident Parkinson's Disease Cohort (ICICLE-PD).

Brain sciences·2020
Same author

Prevalence and duration of non-motor symptoms in prodromal Parkinson's disease.

European journal of neurology·2019
Same author

Cerebral glucose metabolism and cognition in newly diagnosed Parkinson's disease: ICICLE-PD study.

Journal of neurology, neurosurgery, and psychiatry·2017
Same author

Cognitive impairment in Parkinson's disease: impact on quality of life of carers.

International journal of geriatric psychiatry·2016
Same author

Short latency afferent inhibition: Effects of ageing.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2016
Same journal

Development of molecular methods for the identification of aspergillus and emerging moulds in paraffin wax embedded tissue sections.

Molecular pathology : MP·2003
Same journal

Tempero-spatial dissociation between the expression of Fas and apoptosis after coronary occlusion.

Molecular pathology : MP·2003
Same journal

Inverse correlation between high level expression of cyclin E and proliferation index in transitional cell carcinoma of the bladder.

Molecular pathology : MP·2003
Same journal

Nuclear beta catenin as a potential prognostic and diagnostic marker in patients with colorectal cancer from Hong Kong.

Molecular pathology : MP·2003
Same journal

Increased cyclin D1 expression in cancer of the ampulla of Vater: relevance to nuclear beta catenin accumulation and k-ras gene mutation.

Molecular pathology : MP·2003
Same journal

Expression of the cell cycle regulatory proteins p34cdc2, p21waf1, and p53 in node negative invasive ductal breast carcinoma.

Molecular pathology : MP·2003
See all related articles

Multiple system atrophy is a rare neurodegenerative disease characterized by parkinsonism, ataxia, and autonomic failure. Research highlights alpha-synuclein in glial cytoplasmic inclusions, linking it to other synucleinopathies and emphasizing the need for further study.

Area of Science:

  • Neuroscience
  • Neuropathology
  • Genetics

Background:

  • Multiple system atrophy (MSA) is a progressive neurodegenerative disorder affecting adults.
  • Characterized by parkinsonism, ataxia, and autonomic dysfunction, MSA has a poor prognosis.
  • The discovery of glial cytoplasmic inclusions (GCIs) identified oligodendrocytes as key players in MSA pathogenesis.

Purpose of the Study:

  • To define multiple system atrophy as a clinicopathological entity.
  • To investigate the role of oligodendrocytes and alpha-synuclein in MSA.
  • To explore the relationship between MSA and other synucleinopathies.

Main Methods:

  • Clinicopathological studies defining MSA.
  • Immunostaining for alpha-synuclein in GCIs.

Related Experiment Videos

  • Comparative analysis with other alpha-synucleinopathies.

    • Main Results:

    • GCIs, positive for alpha-synuclein, indicate widespread white matter pathology in MSA.
    • Alpha-synuclein in GCIs links MSA to Parkinson's disease and other Lewy body disorders.
    • MSA pathogenesis involves oligodendrocytic dysfunction and cytoskeletal protein abnormalities.

    Conclusions:

    • Multiple system atrophy is a synucleinopathy characterized by alpha-synuclein accumulation in oligodendrocytes.
    • The precise mechanism of fibrillogenesis and primary cellular dysfunction in MSA remains unclear.
    • Urgent research is needed to understand MSA pathogenesis and develop effective treatments.