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Progressive supranuclear palsy.

K Tawana1, D B Ramsden

  • 1Department of Medicine, University of Birmingham, Queen Elizabeth Hospital, Birmingham B15 2TH, UK.

Molecular Pathology : MP
|November 29, 2001
PubMed
Summary
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This review explores the molecular pathology of tau protein, focusing on its brain expression and the role of modifications like hyperphosphorylation in fibril formation. The initial trigger for abnormal tau processing is still unknown.

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Biochemistry

Background:

  • The protein tau is implicated in various neurological disorders.
  • Aberrant tau processing contributes to disease pathogenesis.
  • Understanding tau's molecular pathology is crucial for therapeutic development.

Purpose of the Study:

  • To review the molecular pathology of tau protein.
  • To discuss the role of post-translational modifications in tau fibrillogenesis.
  • To highlight the unknown initiating events in aberrant tau processing.

Main Methods:

  • Literature review of studies on tau protein.
  • Analysis of tau expression patterns in the brain.
  • Examination of post-translational modifications affecting tau.

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Main Results:

  • Tau protein is expressed in diverse brain regions.
  • Post-translational modifications, including hyperphosphorylation and glycation, are key in tau fibrillogenesis.
  • The precise initiating factor for aberrant tau processing remains unidentified.

Conclusions:

  • Tau's molecular pathology is complex, involving regional expression and post-translational modifications.
  • Hyperphosphorylation and glycation significantly influence tau fibril formation.
  • Further research is needed to elucidate the initiating events driving aberrant tau processing.