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Assessment of Resistance to Tyrosine Kinase Inhibitors by an Interrogation of Signal Transduction Pathways by Antibody Arrays
07:42

Assessment of Resistance to Tyrosine Kinase Inhibitors by an Interrogation of Signal Transduction Pathways by Antibody Arrays

Published on: September 19, 2018

Oncogenes, Protein Tyrosine Kinases, and Signal Transduction

D. Liu1, L.-H. Wang

  • 1Department of Microbiology, The Mount Sinai School of Medicine, New York, N.Y., USA.

Journal of Biomedical Science
|March 1, 1994
PubMed

Insights

Oncogenic protein tyrosine kinases (PTKs) transmit signals for cell growth. Their activation and interactions via SH2/SH3 domains are key to understanding oncogenesis and signal transduction.

Area of Science:

  • Molecular Biology
  • Cellular Signaling
  • Oncogenesis

Background:

  • Many oncogenes encode protein tyrosine kinases (PTKs).
  • Mutations lead to constitutive PTK activation, crucial for cell signaling.
  • PTK autophosphorylation and substrate phosphorylation transmit mitogenic signals.

Purpose of the Study:

  • To review recent progress in signal transduction by PTKs.
  • To highlight the role of SH2 and SH3 domains in signal relay.
  • To connect PTK function to cell growth control and oncogenesis.

Main Methods:

  • Review of studies on oncogenes, PTKs, and SH2/SH3-containing proteins.
  • Analysis of protein-protein interactions mediated by SH2/SH3 domains.
  • Examination of phosphotyrosine binding sites for SH2 domains.

Main Results:

  • PTK activation is essential for signal transmission.
  • SH2/SH3 domains mediate signal relay from extracellular signals to the nucleus.
  • Protein tyrosine phosphorylation provides binding sites for SH2 domains.

Conclusions:

  • Studies on PTKs and SH2/SH3 proteins advance understanding of cell growth control.
  • PTKs play a central role in oncogenesis through signal transduction pathways.
  • SH2/SH3-mediated interactions are critical for relaying cellular signals.

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