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The Human Papillomavirus Database.

A.D. Farmer1, C.E. Calef, K. Millman

  • 1Theoretical Biology and Biophysics (T-10), Theory Division, Los Alamos National Laboratory, Los Alamos, N.M., USA.

Journal of Biomedical Science
|April 1, 1995
PubMed
Summary

Human papillomaviruses (HPVs) cause various diseases and are genetically diverse. A specialized database offers sequence analyses to explore HPV evolution, phylogeny, and cross-species transmission.

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Area of Science:

  • Virology
  • Molecular Evolution
  • Bioinformatics

Background:

  • Human papillomaviruses (HPVs) are linked to diseases from warts to cancers.
  • HPVs represent a genetically diverse virus family, serving as a model for DNA virus evolution.

Purpose of the Study:

  • To present the scope of information in the Human Papillomavirus Database and Analysis Project.
  • To outline sequence-based analyses performed on papillomavirus genetic sequences.

Main Methods:

  • Establishment of a specialized genetic sequences database for papillomaviruses.
  • Performing sequence-based analyses including phylogenetic relationships, recombination, and selective pressures.
  • Investigating potential cross-species transmission events.

Main Results:

  • The database provides comprehensive genetic sequence information for papillomaviruses.
  • Analyses reveal insights into HPV phylogenetic relationships and evolutionary dynamics.
  • Evidence for recombination events and selective pressures on HPV genes is presented.
  • The study explores the potential for cross-species transmission of papillomaviruses.

Conclusions:

  • The Human Papillomavirus Database is a valuable resource for studying HPV evolution.
  • Sequence analyses provide critical data for understanding HPV-related diseases and viral evolution.
  • Further research can leverage this database to investigate viral adaptation and transmission.

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