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Use of Interferon-γ Enzyme-linked Immunospot Assay to Characterize Novel T-cell Epitopes of Human Papillomavirus
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Use of Interferon-γ Enzyme-linked Immunospot Assay to Characterize Novel T-cell Epitopes of Human Papillomavirus

Published on: March 8, 2012

Human Papillomavirus Is Associated with Monoclonal Gammopathies of Unknown Significance

D.A. Payne1, T.-s. Chan Ts, B. Ostermeyer Schoaib

  • 1Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Tex., USA.

Journal of Biomedical Science
|September 1, 1996
PubMed

Insights

Human papillomavirus (HPV) DNA was detected in the bone marrow of patients with monoclonal gammopathy of unknown significance (MGUS). This suggests a potential link between HPV and this premalignant condition.

Area of Science:

  • Oncology
  • Virology
  • Hematology

Background:

  • Monoclonal gammopathy of unknown significance (MGUS) is a premalignant condition.
  • MGUS can progress to lymphoproliferative diseases like multiple myeloma.
  • Previous research identified human papillomavirus (HPV) in plasma cell tumors and multiple myeloma bone marrow.

Purpose of the Study:

  • To investigate the presence of HPV in patients with MGUS.
  • To determine if HPV is associated with the premalignant phase of lymphoproliferative diseases.

Main Methods:

  • Bone marrow biopsies from 14 MGUS patients and 26 controls were analyzed.
  • Polymerase chain reaction (PCR) and in situ hybridization were used to detect HPV sequences.

Main Results:

  • HPV sequences were identified in 10 out of 14 MGUS patients.
  • A significant association (p = 0.001) was found between HPV and MGUS.
  • No HPV was detected in normal bone marrow controls.

Conclusions:

  • HPV may reside in the bone marrow of patients with MGUS.
  • These findings suggest a potential role for HPV in the pathogenesis of premalignant lymphoproliferative diseases.

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