Cell Signaling and Heat Shock Protein Expression
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Updated: Oct 3, 2026

Standardized Methods for Measuring Induction of the Heat Shock Response in Caenorhabditis elegans
Published on: July 3, 2020
1Department of Clinical Physiology, Division of Medicine, Walter Reed Army Institute of Research, Washington, D.C., USA.
Abstract:
Exposure of cells and organs to heat shock is associated with numerous changes in various cellular metabolic parameters and overexpression of proteins collectively known as heat shock proteins (HSP). In this communication we review the cell-signaling events that are altered in response to heat shock as they relate to the subsequent induction of HSP 70 kd (HSP-70) expression. We also review the mechanisms by which HSP-70 is involved in conferring cytoprotective effects. The possibility of altering HSP expression through manipulations of the cell-signal process has clinical importance. Copyright 1996 S. Karger AG, Basel
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