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Glycoside in schizophrenic patients sera affects behavior of mouse forced swimming
Y Masuda1, S Ohnuma, J Sugawara
1Department of Neuropsychiatry, Akita University School of Medicine, Japan.
The Tohoku Journal of Experimental Medicine
|December 1, 2001
Abstract:
We found a glycoside in sera of schizophrenic patients. This glycoside increased climbing of mouse forced swimming and the climbing was decreased by dopamine D1 receptor antagonist SCH-23390 with a dose dependent manner. This glycoside had much reactivity of GalNAc alpha1-3GalNAc, but not that of polymannoses nor that of Gal beta1-3GlcNAc alpha1-serine or threonine. This strongly suggests that the glycoside is an isolated O-glycoside, but not N-glycoside nor O-glycoside having core 1 or 2. The present findings suggest that schizophrenic patients have the special glycoside affecting the D1 receptor activity in their serum.