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The HELLP syndrome, a prospective study.

K A Abraham1, G Connolly, J Farrell

  • 1Dept. of Nephrology & Transplantation, Beaumont Hospital, Dublin, Ireland.

Renal Failure
|December 1, 2001
PubMed
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Hemolysis, elevated liver enzymes, and low platelets (HELLP) syndrome is a rare pregnancy complication. Early intervention and monitoring laboratory data are crucial for favorable maternal and fetal outcomes.

Area of Science:

  • Obstetrics and Gynecology
  • Maternal-Fetal Medicine
  • Critical Care in Pregnancy

Background:

  • HELLP syndrome is a severe condition complicating pregnancy.
  • It is characterized by hemolysis, elevated liver enzymes, and low platelet count.
  • Understanding its incidence and outcomes is vital for clinical management.

Purpose of the Study:

  • To determine the incidence and outcomes of HELLP syndrome in Irish pregnant patients.
  • To analyze the duration and trends of associated abnormal laboratory results.
  • To identify factors influencing the syndrome's course and resolution.

Main Methods:

  • Prospective observational study of 12,068 pregnant women from January 1995 to March 1997.
  • Monitoring of women with hypertension, proteinuria, thrombocytopenia, or anemia for hemolysis and elevated liver transaminases.

Related Experiment Videos

  • Follow-up from recruitment until six weeks postpartum or syndrome resolution.

    • Main Results:

    • HELLP syndrome occurred in 0.11% of pregnant women (13 out of 12,068).
    • Hypertension was present in all cases; 84.6% had proteinuria.
    • Delivery was the sole factor terminating the syndrome; 53.8% experienced acute renal dysfunction without requiring dialysis. Laboratory parameters normalized by postpartum day six. Fetal mortality was 7.1% (1/14), with no maternal deaths.

    Conclusions:

    • HELLP syndrome is a rare but serious obstetric complication.
    • Close monitoring of laboratory data and timely intervention are essential.
    • Effective management leads to favorable outcomes for both mother and fetus.