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Related Experiment Videos

Soluble selectin profiles associated with severe trauma.

A Siemiatkowski1, F Rogowski, U Wereszczyńska-Siemiatkowska

  • 1Department of Anesthesiology and Intensive Therapy, Medical Academy of Białystok, Poland. asiemiat@amb.ac.bialystok.pl

Archivum Immunologiae Et Therapiae Experimentalis
|December 1, 2001
PubMed
Summary

Severe trauma increases soluble P- and E-selectin and decreases L-selectin levels, indicating endothelial activation. These selectin changes may help predict patient outcomes after major injury.

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Area of Science:

  • Biomedical Science
  • Trauma Research
  • Inflammation and Immunology

Background:

  • Severe trauma triggers systemic inflammation and mediator release.
  • Selectins, adhesion proteins, mediate neutrophil adherence to endothelium, crucial in post-trauma complications.
  • Understanding selectin dynamics is key to monitoring trauma prognosis.

Purpose of the Study:

  • To track sequential changes in circulating selectin levels after severe injury.
  • To assess the clinical significance of selectins in predicting trauma prognosis and outcome.

Main Methods:

  • Studied 34 severely traumatized patients.
  • Measured serum soluble E-selectin (sE-selectin), plasma soluble P-selectin (sP-selectin), and soluble L-selectin (sL-selectin) concentrations.

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  • Calculated APACHE II scores and monitored patients for 5 days, comparing survivors and non-survivors.

    • Main Results:

    • Initial sP-selectin and sE-selectin levels were significantly elevated in all trauma patients.
    • Higher levels of these selectins correlated with poorer prognosis and outcomes.
    • Survivors showed a consistent decrease in sP-selectin, while non-survivors had persistently low sL-selectin levels.
    • Trauma patients exhibited increased P- and E-selectin and decreased L-selectin concentrations.

    Conclusions:

    • Severe trauma induces widespread microvascular endothelial activation early post-injury.
    • Altered selectin levels suggest increased neutrophil-endothelial adhesion and migration.
    • These selectin markers may serve as valuable early prognostic indicators in severe trauma patients.