Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Fever and cancer in perspective.

U Hobohm1

  • 1F. Hoffmann-La Roche Ltd., Pharma Research, Basel, Switzerland. uwe.hobohm@roche.com

Cancer Immunology, Immunotherapy : CII
|December 1, 2001
PubMed
Summary

Feverish infections may trigger cancer remission, a phenomenon known for centuries. This study explores this link, proposing fever as a potential immunotherapy for certain cancers.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Fever therapy revisited.

British journal of cancer·2005
Same author

Normalization of DNA-microarray data by nonlinear correlation maximization.

Journal of computational biology : a journal of computational molecular cell biology·2003
Same author

Heat shock and oxidative stress-induced exposure of hydrophobic protein domains as common signal in the induction of hsp68.

The Journal of biological chemistry·2000
Same author

Reliable automatic protein identification from matrix-assisted laser desorption/ionization mass spectrometric peptide fingerprints.

Electrophoresis·1999
Same author

Scottish randomised controlled trial of conservation therapy for breast cancer.

Lancet (London, England)·1996
Same author

A sequence property approach to searching protein databases.

Journal of molecular biology·1995

Area of Science:

  • Oncology
  • Immunology
  • Cancer Research

Background:

  • The link between feverish infections and spontaneous cancer remission is historically documented.
  • Previous research has largely consisted of isolated observations, lacking systematic investigation.
  • William Coley's pioneering work on bacterial toxins as a cancer therapy is a key historical reference.

Purpose of the Study:

  • To consolidate existing observations on fever and cancer remission.
  • To develop an immunological hypothesis for fever's anti-cancer effects.
  • To provide a scientific basis for exploring fever as a cancer treatment.

Main Methods:

  • Literature review of historical and contemporary observations.
  • Analysis of William Coley's experimental data and clinical outcomes.
  • Formulation of an immunological hypothesis based on collected evidence.

Main Results:

  • Feverish infections are consistently associated with spontaneous cancer remissions across various studies.
  • William Coley's work demonstrated significant tumor regression in response to bacterial toxin therapy, inducing fever.
  • An immunological mechanism involving heightened immune response during fever is proposed.

Conclusions:

  • Fever induction, when medically supervised, shows potential as a therapeutic strategy.
  • This approach may be particularly relevant for cancers of mesodermal origin.
  • Further research into fever-induced immunotherapy for cancer is warranted.

Related Experiment Videos