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Sulfasalazine-induced extrinsic allergic alveolitis in a patient with psoriatic arthritis
M Woltsche1, I Woltsche-Kahr, G M Roeger
1Hospital Hoergas-Enzenbach, Department of Pulmonary Medicine, Hoergas 30, A-8112 Gratwein, Austria. michael.woltsche@lkh-hoergas.at
Abstract:
We report the first case of a well defined extrinsic allergic alveolitis as a complication of sulfasalazine therapy in a patient treated for psoriatic arthritis. CT of the chest showed small nodular densities over both lungs, BAL demonstrated a highly active lymphocytic alveolitis and transbronchial biopsies revealed lymphoplasmocytic interstitial infiltration. Sulfasalazine as causative agent was proven by an inadvertent rechallenge three years later and a positive lymphocyte transformation test. sulfasalazine; psoriatic arthritis; extrinsic allergic alveolitis
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