Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Generalized tonic-clonic activity after remifentanil administration.

G W Haber1, R S Litman

  • 1Department of Anesthesiology, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA.

Anesthesia and Analgesia
|December 1, 2001
PubMed
Summary

This study reports seizure-like activity in an adult after remifentanil administration. Opioid use can trigger generalized tonic-clonic seizure-like events, a phenomenon termed "opioid-seizure syndrome."

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Feedback and constraints: rethinking medication safety countermeasures.

British journal of anaesthesia·2018
Same author

How to prevent medication errors in the operating room? Take away the human factor.

British journal of anaesthesia·2018
Same author

Oxygen supplementation during prolonged tracheal intubation should be the standard of care.

British journal of anaesthesia·2017
Same author

Paediatric anaesthesia outside the operating room.

Current opinion in anaesthesiology·2006
Same author

Anesthesia and analgesia for newborn circumcision.

Obstetrical & gynecological survey·2001
Same author

Anesthesia for tracheal or bronchial foreign body removal in children: an analysis of ninety-four cases.

Anesthesia and analgesia·2000

Area of Science:

  • Anesthesiology
  • Neuroscience
  • Pharmacology

Background:

  • Remifentanil is a potent ultra-short-acting opioid analgesic.
  • Opioid-induced neuroexcitation is a known but rare phenomenon.
  • Generalized tonic-clonic seizures are typically associated with epilepsy or other neurological conditions.

Observation:

  • An adult patient receiving remifentanil experienced seizure-like activity.
  • The event presented as generalized tonic-clonic seizure-like activity.
  • This is the first documented instance in an adult patient.

Findings:

  • Opioid administration, specifically remifentanil, can precipitate seizure-like activity.
  • The observed activity mimicked generalized tonic-clonic seizures.

Related Experiment Videos

  • This association highlights a potential adverse effect of potent opioids.

    • Implications:

    • This report suggests a link between remifentanil and seizure-like events.
    • The term "opioid-seizure syndrome" is proposed for this reaction.
    • Clinicians should be aware of this potential opioid-related neurological complication.