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Published on: February 9, 2021
[Renal oxalosis with renal failure after infusion of xylitol]
1Nephrologische Gemeinschaftspraxis Köln Ehrenfeld. leidig@niere-koeln.de
History And Findings:
Ten days after a complication-free operation for early gastric cancer a 61-year old man had a seizure and acute renal failure.
Investigations:
A percutaneous renal biopsy was performed to find the cause of the renal failure, which at times required several sessions of haemodialysis.
Treatment And Course:
The seizure was thought to have been due to cerebrovascular deposits of oxalate crystals (renocerebral oxalosis). Parenteral xylitol had been given postoperatively, as a glucose substitute (total dose 1560g), together with other routine drugs. Primary oxalosis and other causes of secondary oxalosis had been excluded.
Conclusion:
Xylitol should not be used parenterally as a glucose substitute (banned in the USA).
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