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Updated: Jul 12, 2026
07:18
HLA-Ig Based Artificial Antigen Presenting Cells for Efficient ex vivo Expansion of Human CTL
Published on: April 11, 2011
Summary
The W27 antigen is highly prevalent in ankylosing spondylitis and Reiter syndrome. Its presence strongly correlates with sacroiliitis in axial arthropathies, aiding early disease detection.
Area of Science:
- Immunogenetics
- Rheumatology
- Clinical Medicine
Background:
- The histocompatibility antigen W27 is associated with specific inflammatory arthropathies.
- Ankylosing spondylitis and Reiter syndrome frequently exhibit high W27 antigen incidence.
Purpose of the Study:
- To investigate the correlation between W27 antigen and clinical manifestations in axial arthropathies.
- To assess the utility of W27 antigen detection in diagnosing early or atypical forms of arthritis.
Main Methods:
- Tissue typing techniques were employed to identify the presence of the W27 antigen.
- Clinical data including symptom extent, duration, and sacroiliitis were analyzed in relation to W27 status.
Main Results:
- A high incidence of W27 antigen was observed in ankylosing spondylitis (96%) and Reiter syndrome (74%).
- No correlation was found between W27 antigen and symptom extent or duration in Reiter syndrome patients.
- Sacroiliitis was predominantly observed in patients with the W27 antigen across all axial arthropathies studied.
Conclusions:
- The W27 antigen is a significant marker in axial arthropathies, particularly associated with sacroiliitis.
- Tissue-typing for W27 antigen may assist in the early or atypical diagnosis of these conditions.
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