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Updated: Jul 16, 2026

Ovariectomy and 17β-estradiol Replacement in Rats and Mice: A Visual Demonstration
Published on: June 7, 2012
Managing the transition from oral contraceptives to hormone replacement therapy
Abstract:
Oral contraceptives provide multiple benefits for perimenopausal women; their use results in considerable economic savings by managing vasomotor symptoms, preventing pregnancy, and improving future outcomes. Hormone replacement therapy provides many health benefits for menopausal women; a recently introduced constant estrogen/intermittent progestin regimen takes advantage of receptor dynamics and the extended half-life of norgestimate to provide a continuous progestational effect on the endometrium. The lower progestin dose may also decrease progestin-related side effects and contribute to increased adherence and treatment continuation.
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