Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Gene therapy for high grade gliomas.

J B Alavi1, S L Eck

  • 1Hematology-Oncology Division, Department of Medicine, University of Pennsylvania, 3400 Spruce St., Philadelphia 19104, USA. jalavi@mail.med.upenn.edu

Expert Opinion on Biological Therapy
|December 1, 2001
PubMed
Summary

Gene therapy shows promise for high-grade gliomas, offering a new approach beyond traditional treatments. Clinical trials demonstrate manageable toxicity and potential anti-tumor effects, paving the way for future advancements.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Biomarker qualification via public-private partnerships.

Clinical pharmacology and therapeutics·2009
Same author

A simplified one-pot synthesis of 9-[(3-[18F]fluoro-1-hydroxy-2-propoxy)methyl]guanine([18F]FHPG) and 9-(4-[18F]fluoro-3-hydroxymethylbutyl)guanine ([18F]FHBG) for gene therapy.

Nuclear medicine and biology·2001
Same author

Importance of dose intensity in neuro-oncology clinical trials: summary report of the Sixth Annual Meeting of the Blood-Brain Barrier Disruption Consortium.

Neuro-oncology·2001
Same author

Imaging in vivo herpes simplex virus thymidine kinase gene transfer to tumour-bearing rodents using positron emission tomography and.

European journal of nuclear medicine·2001
Same author

Treatment of recurrent or progressive malignant glioma with a recombinant adenovirus expressing human interferon-beta (H5.010CMVhIFN-beta): a phase I trial.

Human gene therapy·2001
Same author

Multiple intraabdominal soft-tissue masses in a man awaiting liver transplantation: a case study and discussion.

American journal of clinical oncology·2000

Area of Science:

  • Neuro-oncology
  • Molecular therapy
  • Clinical gene transfer

Background:

  • High-grade gliomas (HGGs) are aggressive brain tumors with poor prognoses.
  • Current systemic therapies like chemotherapy and immunotherapy have limited efficacy in HGGs.
  • Local treatments offer better outcomes but are insufficient for complete eradication.

Purpose of the Study:

  • To review completed and ongoing gene therapy clinical protocols for adult gliomas.
  • To summarize the methodologies and outcomes of these gene therapy trials.
  • To identify future directions for gene therapy in glioma treatment.

Main Methods:

  • Direct intratumoral injection of viral vectors into gliomas.
  • Utilized vectors include retroviruses, adenoviruses, and oncolytic viruses.
  • Gene therapy strategies encompass prodrug activation (HSVtk/ganciclovir), p53, and IFN-beta gene transfer.

Main Results:

  • Phase I clinical studies indicate low to moderate toxicity.
  • Variable levels of gene transfer efficiency were observed.
  • Some studies reported evidence of anti-tumor effects.

Conclusions:

  • Gene therapy represents a promising addition to HGG management.
  • Improvements in gene delivery systems are crucial for enhanced efficacy.
  • Combination of gene therapy with other modalities holds significant future potential.

Related Experiment Videos