Related Experiment Video
Updated: Aug 2, 2026
06:44
Creation of Abdominal Adhesions in Mice
Published on: August 27, 2016
Introduction--prevention of adhesion formation: the journey continues
1Department of Obstetrics and Gynecology, McGill University, Montreal, Quebec, Canada. togas.tulandi@muhc.mcgill.ca
Human Reproduction Update
|December 1, 2001
Summary
Intra-abdominal adhesions are a common surgical complication causing significant healthcare costs and issues like infertility and bowel obstruction in gynecology.
Area of Science:
- Surgical Complications
- Gastroenterology
- Gynecologic Surgery
Background:
- Intra-abdominal adhesions are a frequent complication following abdominal surgery.
- These adhesions significantly impact patient health and incur substantial healthcare costs.
Discussion:
- Adhesion-related issues in gynecology include infertility, chronic abdominal pain, and bowel obstruction.
- The economic burden of managing adhesion-related problems is considerable.
Key Insights:
- Adhesions pose a significant challenge in abdominal and gynecologic surgery.
- Effective adhesion prevention and management strategies are crucial.
Outlook:
- Further research into adhesion prevention is needed.
- Minimizing adhesion formation can improve patient outcomes and reduce healthcare expenditure.
Related Concept Videos
01:14Adhesion
Adhesion occurs when one type of molecule is attracted to a different molecule. Water exhibits adhesive properties in the presence of polar surfaces, such as glass or cellulose in plants. For instance, when water is poured into a glass, the positively charged hydrogen molecules of water are more attracted to the negatively charged oxygen molecules in the silica than to the oxygen in neighboring water molecules.
Capillary action is a result of water’s adhesive tendencies. When a narrow glass...
Capillary action is a result of water’s adhesive tendencies. When a narrow glass...
01:09Cell Migration
Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
01:19Cell Migration
Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
01:03Anchoring Junctions
Anchoring junctions are multiprotein complexes that help cells connect to other cells and the extracellular matrix. Anchoring junctions are present on the lateral and basal surfaces of cells, providing strong and flexible connections. Focal adhesions are often formed due to cell interactions with the ECM substrata, which initiate signal transduction via kinase cascades and other mechanisms. Together, they provide stability and tissue integrity. There are three types of anchoring junctions:...
01:24Adherens Junctions
Strong contact points between adjacent cells anchor them to each other, forming tissues. Such anchoring junctions are of two types – adherens junctions and desmosomes. Adherens junctions are abundant in tissues such as epithelium and endothelium, forming a continuous zone of adhesion called the adhesion belt. In other tissues, such as heart muscle, they appear as clusters, linking the cells to produce coordinated heart muscle contraction.
Adherens Junctions are Dynamic
The endothelial cells...
Adherens Junctions are Dynamic
The endothelial cells...
01:26Tension Response at Adherens Junctions
The adherens junctions that anchor cells together are multi-protein complexes that dynamically adapt to mechanical stimuli such as tensile forces and shear stress. Mechanosensory proteins in these junctions can sense such mechanical stimuli and undergo a shift in their conformation, resulting in an altered function — a process called mechanotransduction.
α-Catenin as a Mechanosensory Protein
The α-catenin of adherens junctions is an allosteric protein with three VH (vinculin homology) domains...
α-Catenin as a Mechanosensory Protein
The α-catenin of adherens junctions is an allosteric protein with three VH (vinculin homology) domains...