Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Genetic analysis in the Asthma Clinical Research Network.

P E Forand1, S J Kunselman, J M Drazen

  • 1Department of Health Evaluation Sciences, College of Medicine, Pennsylvania State University, Hershey, PA, USA.

Controlled Clinical Trials
|December 1, 2001
PubMed
Summary

Genetic analysis of asthma patients is crucial for understanding varied treatment responses. This study outlines best practices for collecting and managing blood samples in clinical trials to ensure data integrity and patient confidentiality.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Structural and Energetic Effects of the 2-Amino and 2'- and 3'-Hydroxy Substituents of Protonated Guanosine Nucleosides: IRMPD, ER-CID, and Theoretical Studies of Protonated Guanosine and Inosine Nucleosides.

Journal of the American Society for Mass Spectrometry·2025
Same author

Influence of 2'-Modifications (O-Methylation, Fluorination, and Stereochemical Inversion) on the Base Pairing Energies of Protonated Cytidine Nucleoside Analogue Base Pairs: Implications for the Stabilities of

Journal of the American Society for Mass Spectrometry·2023
Same author

Structural Determination of Lysine-Linked Cisplatin Complexes via IRMPD Action Spectroscopy: NN<sub>s</sub> and NO<sup>-</sup> Binding Modes of Lysine to Platinum Coexist.

The journal of physical chemistry. B·2022
Same author

5-Halogenation of Uridine Suppresses Protonation-Induced Tautomerization and Enhances Glycosidic Bond Stability of Protonated Uridine: Investigations via IRMPD Action Spectroscopy, ER-CID Experiments, and Theoretical Calculations.

Journal of the American Society for Mass Spectrometry·2022
Same author

Influence of 5-Halogenation on the Base-Pairing Energies of Protonated Cytidine Nucleoside Analogue Base Pairs: Implications for the Stabilities of Synthetic <i>i</i>-Motif Structures for DNA Nanotechnology Applications.

Journal of the American Society for Mass Spectrometry·2022
Same author

Pharmacodynamic genome-wide association study identifies new responsive loci for glucocorticoid intervention in asthma.

The pharmacogenomics journal·2015

Area of Science:

  • Pharmacogenomics
  • Clinical Trial Management
  • Asthma Research

Background:

  • Genetic variations influence individual responses to asthma treatments.
  • Understanding these variations is key to personalized medicine in asthma care.
  • Clinical trials require robust methods for genetic data collection.

Purpose of the Study:

  • To detail the essential procedures for implementing a genetic-analysis database for the Asthma Clinical Research Network.
  • To address critical operational aspects of genetic sample handling in asthma clinical trials.
  • To ensure the quality and integrity of genetic data derived from clinical trial participants.

Main Methods:

  • Establishing protocols for maintaining subject confidentiality during genetic analysis.

Related Experiment Videos

  • Implementing standardized procedures for tracking and shipping biological samples.
  • Defining quality control measures for laboratory genotyping processes.
  • Developing data verification checks for the genetic-analysis database.

    • Main Results:

    • The article provides a framework for managing genetic data in multi-center asthma research.
    • It highlights the importance of meticulous sample handling from collection to analysis.
    • Key considerations for data accuracy and regulatory compliance are discussed.

    Conclusions:

    • Effective implementation of a genetic-analysis database requires careful attention to sample management, quality control, and data verification.
    • Standardized procedures are vital for ensuring reliable genetic data in asthma clinical trials.
    • This approach supports the network's goal of investigating genetic influences on asthma treatment outcomes.