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An Orthotopic Endometrial Cancer Model with Retroperitoneal Lymphadenopathy Made From In Vivo Propagated and Cultured VX2 Cells
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Synchronous vulvar and breast cancer

A Abu-Musa1, A Khalil, G Ghaziri

  • 1Department of Obstetrics and Gynecology, American University of Beirut Medical Center, P.O. Box 113-6044-6A, Beirut, Lebanon. aa06@aub.edu.lb

European Journal of Obstetrics, Gynecology, and Reproductive Biology
|December 1, 2001
PubMed

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Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
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Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
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