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Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

Turkish population data with the CODIS multiplex short tandem repeat loci.

B S Akbasak¹, B Budowle, D J Reeder

¹Medical Biology and Genetics Department, Faculty of Medicine, Inonu University, Malatya, Turkey.

Forensic Science International

|December 1, 2001

Summary

This summary is machine-generated.

This study determined allele frequencies for 13 tetrameric short tandem repeat (STR) loci in 198 Turkish individuals. These genetic markers are crucial for forensic science and population genetics research.

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Area of Science:

Forensic Genetics
Population Genetics
Human Genetics

Background:

Short tandem repeats (STRs) are highly polymorphic DNA regions.
STR analysis is a cornerstone of forensic identification and population studies.
Understanding allele frequencies in specific populations is essential for accurate genetic profiling.

Purpose of the Study:

To establish allele frequency data for 13 tetrameric STR loci in a Turkish population.
To provide a genetic dataset for forensic applications and anthropological research within Turkey.
To contribute to the global database of human genetic variation.

Main Methods:

Genomic DNA was extracted from 198 Turkish blood samples.
Thirteen tetrameric STR loci (CSF1PO, D18S51, D3S1358, D21S11, D5S818, FGA, D7S820, HUMTH01, D8S1179, TPOX, D13S317, VWA, and D16S539) were amplified using PCR.
Allele frequencies were calculated based on the amplified STR profiles.

Main Results:

Allele frequencies for all 13 STR loci were determined in the Turkish cohort.
The data provides a comprehensive genetic profile for the studied population.
Specific allele distributions were observed across the analyzed STR loci.

Conclusions:

The determined STR allele frequencies are valuable for forensic casework in Turkey.
This dataset aids in understanding the genetic landscape of the Turkish population.
The findings support the use of these STR loci for human identification and population genetics studies.