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Related Experiment Videos

Emergency department D-dimer testing.

A T Sadosty1, D G Goyal, E T Boie

  • 1Department of Emergency Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA.

The Journal of Emergency Medicine
|December 1, 2001
PubMed
Summary
This summary is machine-generated.

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D-dimer assays are emerging as a valuable biochemical marker for screening venous thromboembolism. This review covers the scientific basis, available tests, and clinical utility of D-dimer in patient evaluation.

Area of Science:

  • Biochemistry
  • Hematology
  • Clinical Diagnostics

Background:

  • Venous thromboembolism (VTE) diagnosis requires reliable biochemical markers.
  • D-dimers, fibrinolysis derivatives, show promise for VTE screening.
  • Development of sensitive and specific VTE markers has been a focus since the 1980s.

Purpose of the Study:

  • To review the physiologic, pathologic, and chemical basis of D-dimer testing for VTE.
  • To outline currently available D-dimer assays.
  • To discuss the clinical utility of D-dimer in evaluating patients with suspected VTE.

Main Methods:

  • Literature review of D-dimer physiology and pathology.
  • Survey of commercially available D-dimer assays.
  • Analysis of clinical studies on D-dimer utility in VTE diagnosis.

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Main Results:

  • D-dimers reflect fibrinolysis, a key process in VTE.
  • Various D-dimer assays exist, differing in sensitivity and specificity.
  • Clinical utility varies depending on pre-test probability and assay characteristics.

Conclusions:

  • D-dimer testing is a valuable tool in the diagnostic workup of VTE.
  • Appropriate use of D-dimer assays can help rule out VTE in low-risk patients.
  • Further research may refine the role of D-dimer in specific clinical scenarios.