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Related Experiment Videos

Malignancy and the benign lymphoepithelial lesion.

J G Batsakis, E G Bernacki, D H Rice

    The Laryngoscope
    |February 1, 1975
    PubMed
    Summary

    Benign lymphoepithelial lesions of salivary glands can develop into malignancy, including intra-salivary lymphomas and anaplastic carcinomas. These lesions may also present with pseudolymphomatous hyperplasia in multiple organs, even without autoimmune disorders.

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    Area of Science:

    • Pathology
    • Oncology
    • Immunology

    Background:

    • Benign lymphoepithelial lesions (BLEL) are key indicators for various salivary gland disorders.
    • Malignancy developing within BLEL is rare, originating from epithelial or lymphoreticular elements.
    • Associated lymphomas and pseudolymphomas are typically extra-salivary and linked to Sjögren's syndrome; epithelial malignancies are usually anaplastic and not autoimmune-related.

    Purpose of the Study:

    • To report cases of intra-salivary lymphomas and anaplastic carcinomas arising in BLEL.
    • To illustrate potential multiple organ involvement in BLEL, including pseudolymphomatous hyperplasia.
    • To highlight variations in presentation and association with autoimmune disorders.

    Main Methods:

    • Case series presentation.

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  • Histopathological analysis of salivary gland and other organ tissues.
  • Clinical correlation of patient findings.

    • Main Results:

    • Two patients developed intra-salivary lymphomas within BLEL.
    • One patient presented with anaplastic carcinoma originating in the epithelial component of BLEL.
    • A fourth patient showed pseudolymphomatous lymphoreticular hyperplasia in the lung and submandibular gland, indicating possible multi-organ involvement without autoimmune disease.

    Conclusions:

    • Intra-salivary lymphomas and anaplastic carcinomas can arise in benign lymphoepithelial lesions.
    • Benign lymphoepithelial lesions may manifest with extraglandular pseudolymphomatous involvement, potentially without concurrent autoimmune conditions.
    • These findings expand the understanding of the diverse pathological spectrum associated with benign lymphoepithelial lesions of salivary glands.